The apostle Paul writes Timothy, his favorite “son in the faith” from the old Mamertine Prison in Rome. He has been condemned to death and realizes there is no chance of acquittal. His faith is being subjected to its greatest test, but he testifies to one in whom he trusts to carry on the ministry of the gospel: I am not ashamed, because I know whom I have believed, and am convinced that he is able to guard what I have entrusted to him for that day (II Tim. 1:12, NIV).
Paul hoped he might see the face of Timothy before his execution. But at this time the younger man is on assignment to the church in Ephesus. Whether or not they ever meet again in this life, Paul wants his younger colleague to know the secret of being faithful to the divine call to preach the Gospel. He reminds Timothy of a time back in Lystra when in a service he had laid hands on him (possibly in consecration or ordination). There is no doubt in my mind that this is a reference to the time when Timothy was filled with the Holy Spirit—given not a spirit of timidity, but a spirit of power, of love and of self-discipline.